Molecular mechanisms of juvenile hormone in insect metamorphosis
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ACTA ENTOMOLOGICA SINICA  2017, Vol. 60 Issue (5): 594-603    DOI: 10.16380/j.kcxb.2017.05.012
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Molecular mechanisms of juvenile hormone in insect metamorphosis
HE Qian-Yu1, ZHANG Yuan-Xi2, PEI Ze-Hua3, LI Mei-Xin1, ZHANG Xu1,*
(1. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, China; 2. Environmental Monitoring Center Station, Daqing Environmental Protection Agency, Daqing, Heilongjiang 163316, China; 3. College of Food Science, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, China)
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Abstract Since Methoprene tolerant (Met) was identified as the juvenile hormone receptor, great progress has been made in understanding the molecular mechanisms of juvenile hormone (JH) in insect metamorphosis. In this article, we summarized the identification of Met and the regulation of chaperone protein Hsp83 and Nuclearporin Nup358 on Met cellular localization, focusing on the roles of JH-Met-Kr-h1-Br signal pathway in larval-pupal metamorphosis of holometabolous insects, and JH-Met-Kr-h1-E93 signal pathway in adult metamorphosis of hemimetabolous and holometabolous insects. Moreover, the roles of many molecular interactions in JH-20E crosstalk were discussed. These interactions include the binding between Met and 20-hydroxyecdysone nuclear receptor EcR/USP, the interaction of Tai/SRC/FISC with Met and EcR/USP to form JH and 20E functional receptors respectively, the activation of JH on 20E responsive gene E75A, and the association between JH and USP. The research progress of the mechanism that JH plays its physiological function through binding to the membrane receptor to activate PKC and PLC signalling was also overviewed.  
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HE Qian-Yu
PEI Ze-Hua
LI Mei-Xin
Key wordsJuvenile hormone   receptor   metamorphosis   molecular mechanism   membrane receptor   signal pathway     
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HE Qian-Yu,ZHANG Yuan-Xi,PEI Ze-Hua et al. Molecular mechanisms of juvenile hormone in insect metamorphosis[J]. ACTA ENTOMOLOGICA SINICA, 2017, 60(5): 594-603.
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