%A %T Effects of four podophyllotoxin analogues on spontaneous action potentials of the ventral nerve cord of Periplaneta americana (Blattaria: Blattidae) %0 Journal Article %D 2009 %J Acta Entomologica Sinica %R %P 168-174 %V 52 %N 2 %U {http://www.insect.org.cn/CN/abstract/article_4498.shtml} %8 2009-03-18 %X The effects of four podophyllotoxin analogues on spontaneous action potentials of the ventral nerve cord of Periplaneta americana were observed by electrophysiology technique. The results showed that at the concertration of 0.1 mmol/L, the four compounds showed different effects on spontaneous action potentials. Dexoypodophyllotoxin exerted irreversible inhibitory effect. β-apopicropodophyllotoxin first exerted excitation and then showed inhibitory effects. Podophyllotoxin showed inhibitory effect, while 4′-demethylpodophyllotoxin did not. The results suggest that the effects of podophyllotoxin analogues on spontaneous action potentials are different according to their structural varieties.