昆虫学报 ›› 2019, Vol. 62 ›› Issue (6): 769-778.doi: 10.16380/j.kcxb.2019.06.012

• 综 述 • 上一篇    下一篇

微小RNA和长链非编码RNA介导的昼夜节律调控

王丹凤1,2,3,4,#, 杨广1,2,3,4,#, 陈文锋5,*   

  1.  (1. 福建农林大学应用生态研究所, 闽台作物有害生物生态防控国家重点实验室, 福州 350002; 2. 福建农林大学, 教育部害虫生态防控国际合作联合实验室, 福州 350002; 3. 福建农林大学, 农业部闽台作物有害生物综合治理重点实验室, 福州 350002; 4. 福建农林大学, 害虫绿色防控福建省高等学校重点实验室, 福州 350002; 5. 福州大学生物科学与工程学院, 福州 350108)
  • 出版日期:2019-06-20 发布日期:2019-06-04

miRNA- and lncRNA-mediated regulation of circadian rhythms

WANG Dan-Feng1,2,3,4,#, YANG Guang1,2,3,4,#, CHEN Wen-Feng5,*   

  1. (1. State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China; 2. Joint International Research Laboratory of Ecological Pest Control, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China; 3. Key Laboratory of Integrated Pest Management for FujianTaiwan Crops, Ministry of Agriculture, Fujian Agriculture and Forestry University, Fuzhou 350002, China; 4. Key Laboratory of Green Pest Control, Fujian Province University, Fujian Agriculture and Forestry University, Fuzhou 350002, China; 5. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China)
  • Online:2019-06-20 Published:2019-06-04

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摘要：

 非编码RNA(ncRNA)是生物体细胞内一类重要的调控分子，其介导的昼夜节律调控日益受到研究者的重视。本文主要以黑腹果蝇Drosophila melanogaster和哺乳动物的相关研究为背景，阐述了微小RNA(miRNA)和长链非编码RNA(lncRNA)对昼夜节律的调控。miRNA介导的昼夜节律调控包括：生物体内(尤其是钟神经元中)具有节律性表达的miRNA；输入系统和miRNA存在相互调控，这主要是通过光照这个授时因子起作用；miRNA可直接调控核心振荡器，还可以调控其他基因而间接影响到核心振荡器；miRNA对输出系统的调控主要集中在代谢取食节律、运动节律、睡眠节律等。昼夜节律可调控lncRNA的表达，同时lncRNA也可调控昼夜节律，且lncRNA对基因调控范围广，作用机制复杂，这些都具有广阔的研究前景。本文将有助于进一步深入研究ncRNA对昼夜节律的调控。

关键词: 果蝇, 哺乳动物, 非编码RNA, 微小RNA, 长链非编码RNA, 昼夜节律

Abstract: Non-coding RNAs (ncRNAs) are a family of important regulatory molecules in organisms, and the regulation of circadian rhythms by ncRNAs has received increasing attention from researchers. In this article, we reviewed the regulation of circadian rhythms by microRNAs (miRNAs) and long-chain non-coding RNAs (lncRNAs) in the context of the related studies of Drosophila melanogaster and mammals. miRNA-mediated regulation of circadian rhythms includes: there are miRNAs with rhythmic expression in organisms, especially in clock neurons; the interaction between input systems and miRNAs mainly via the zeitgeber of light; miRNAs can directly regulate the core oscillator or indirectly affect the core oscillator by regulating other genes; and the regulation of miRNAs on the output system mainly focuses on metabolic feeding rhythms, locomotion rhythms, and sleep rhythms. The circadian rhythm and lncRNAs can regulate each other, and lncRNAs have a wide range of effects and complex mechanisms, which has broad research prospects. This article will be useful for further studies on the regulation of circadian rhythms by non-coding RNAs.

Key words: Drosophila, mammal, ncRNA, microRNA, lncRNA, circadian rhythm

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