关键词: 浓核病毒, 家蚕, 组织病理学特征

Abstract: A small icosahedral nonenveloped DNA virus with the main biological and biophysical properties of densoviruses (DNVs) was isolated from silkworm Bombyx mori with abnormal larval mortality. Histopathological studies suggested that the virus first parasited on columnar cell of midgut, and then the nucleus of columnar cell became extremely inflated, or even broken. In situ hybridization results also demonstrated the virus was first reproduced in nucleus of columnar cells among midgut epithelial cells. It can also infect and reproduce in the goblet cells and most of the larval tissues at the last stage of infected silkworm.

Key words: Densovirus, Bombyx mori, histopathological characteristics