[反]-β-法尼烯与氟取代物分子结构叠合差异分析

›› 2002, Vol. 45 ›› Issue (6): 844-846.

[反]-β-法尼烯与氟取代物分子结构叠合差异分析

阚炜¹，张钟宁^1*，杨新玲²，黄文耀²

出版日期:2002-12-20 发布日期:2002-12-20

A preliminary analysis of structural differences between[E]-β-farnesene and its fluorine containing derivatives

KAN Wei¹, ZHANG Zhong-Ning^1*, YANG Xin-Ling², HUANG Wen-Yao²

Online:2002-12-20 Published:2002-12-20

摘要/Abstract

摘要： 利用计算机辅助分子叠合法对蚜虫报警信息素［反］-β-法尼烯(EBF)的氟取代系列物与EBF的结构进行比较，初步研究了EBF及其氟取代系列物的结构活性之间的关系。发现对于1氟、2氟及3氟的取代物来说，在分子骨架共轭双键端进行氟取代修饰，所得取代物结构与EBF最为近似，可能具有生物报警活性。

关键词: [反]-β-法尼烯, 蚜虫报警信息素, 氟取代物, 结构活性

Abstract: A preliminary study of the structural activity and relationship between EBF and its derivatives was conducted by comparing the structure of the aphid alarm pheromone (EBF) with its fluoro derivatives using computer molecular fitting. This demonstrated that these derivatives, which are substituted by one, two or three fluorine molecules in the conjugated diene of EBF, are similar to EBF in structure. They could possibly be active in bioassay.

Key words: [E]-β-farnesene, aphid alarm pheromone, fluoro derivatives, structureactivity

阚炜¹，张钟宁^1*，杨新玲²，黄文耀². [反]-β-法尼烯与氟取代物分子结构叠合差异分析[J]. , 2002, 45(6): 844-846.

KAN Wei¹, ZHANG Zhong-Ning^1*, YANG Xin-Ling², HUANG Wen-Yao². A preliminary analysis of structural differences between[E]-β-farnesene and its fluorine containing derivatives[J]. , 2002, 45(6): 844-846.