›› 2006, Vol. 49 ›› Issue (1): 118-125.

• 研究论文 • 上一篇    下一篇

果蝇蜕皮激素诱导程序性细胞死亡的遗传调控因子

李庆荣, 邓小娟, 杨婉莹, 黄志君, 钟仰进, 曹阳, 夏庆友   

  1. 华南农业大学蚕学分子生物学与生物技术实验室
  • 出版日期:2006-03-03 发布日期:2006-02-20
  • 通讯作者: 曹阳

Genetic regulators involved in ecdysone-induced programmed cell death in Drosophila

LI Qing-Rong, DENG Xiao-Juan, YANG Wan-Ying, HUANG Zhi-Jun, ZHONG Yang-Jin, CAO Yang, XIA Qing-You   

  1. South China Agricultural University
  • Online:2006-03-03 Published:2006-02-20

摘要: 近年来关于果蝇程序性细胞死亡(programmed cell death, PCD)的研究结果表明,在果蝇的变态发育过程中,蜕皮激素与受体结合后诱导转录因子的表达。这些转录因子作为程序性细胞死亡调控网络中的初、次级应答信号,激活凋亡诱导因子Reaper、Hid和Grim的表达。Reaper、Hid和Grim进而阻止凋亡蛋白抑制因子的活性,从而启动半胱氨酸蛋白酶caspase途径,引起细胞凋亡(apoptosis)。该文综述了蜕皮激素诱导的果蝇程序性细胞死亡中各遗传调控因子之间的关系。

关键词: 果蝇, 蜕皮激素, 蜕皮酮, 程序性细胞死亡, 细胞凋亡, 遗传调控因子

Abstract:

Recent reports on programmed cell death (PCD)(or apoptosis) in Drosophila reveal that during metamorphosis, binding of ecdysone to the complex of ecdysone receptor and ultraspiracle results in expression of the transcription factors that are primarily and secondarily responsive to PCD signals in the regulatory networks. These transcription factors activate the expression of inducers (Reaper, Hid, and Grim) of apoptosis and the activated inducers suppress activity of inhibitors of apoptosis proteins, resulting in onset of the caspase-dependent apoptosis. The genetic regulators that are involved in the ecdysone-induced programmed cell death in Drosophila and their relationship between each other were reviewed in this article.

Key words: Drosophila, molting hormone, ecdysone, programmed cell death, apoptosis, genetic regulator