›› 2006, Vol. 49 ›› Issue (6): 1009-1016.

• 研究论文 • 上一篇    下一篇

Bt杀虫晶体蛋白受体分子的结构与功能

王莉,李学锋, 徐宝仁, 吴青君, 张友军*   

  1. (中国农业科学院蔬菜花卉研究所,北京100081)
  • 出版日期:2006-12-31 发布日期:2006-12-20
  • 通讯作者: 张友军

Advances in research on molecular structure and function of Bt (Bacillus thuringiensis) receptors in insects

WANG Li, LI Xue-Feng, XU Bao-Ren, WU Qing-Jun, ZHANG You-Jun   

  1. (Institute of Vegetables and Flowers, Chinese Academy of Agricultural Science, Beijing 100081, China)
  • Online:2006-12-31 Published:2006-12-20
  • Contact: ZHANG You-Jun

摘要: 苏云金杆菌(Bacillus thuringiensis Bt)杀虫蛋白与昆虫中肠细胞膜上受体的结合是Bt毒素作用的关键环节和决定Bt杀虫蛋白选择性的关键因素。受体与Bt杀虫蛋白结合能力的改变可能是昆虫对Bt产生抗性的主要原因,也因此成为近年来国际上的研究热点和焦点,并取得了突破性的进展。该文就昆虫体内Bt毒素的4种受体:氨肽酶N、类钙粘蛋白、碱性磷酸酶以及最近报道的糖脂类受体的结构、功能、受体与毒素的结合特性、受体基因在离体细胞中的表达特性以及受体基因的突变与害虫对Bt毒素的抗性等方面进行了综述。

关键词: 昆虫, Bt, 受体, 结构, 功能

Abstract: Bacillus thuringiensis (Bt) receptor is very important to the toxicity expression of Bt in insects. Change in binding ability between this receptor and Bt insecticidal proteins may be the main mechanism of Bt resistance. In this paper, the types, structure, binding characteristics of the insect receptors, including aminopeptidase N, cadherin-like protein, alkaline phosphatase and glycolipids, the expression of genes of insect receptors in endogenous cells, and the relationships between Bt resistance and receptor are reviewed.

Key words: Insect, Bacillus thuringiensis, receptor, structure, function