›› 2007, Vol. 50 ›› Issue (12): 1285-1292.

• 研究论文 • 上一篇    下一篇

保幼激素合成的研究进展

刘艳,胜振涛,蒋容静,黄原,李胜   

  • 出版日期:2007-12-20 发布日期:2008-01-04
  • 通讯作者: 李胜

Progress in juvenile hormone synthesis

  • Online:2007-12-20 Published:2008-01-04

摘要: 保幼激素 (juvenile hormone,JH) 是通过甲羟戊酸途径合成的一类倍半萜化合物。以昆虫中普遍存在的JH Ⅲ为例,从分子水平上概述了JH合成途径中的各种酶,并对其中的两个关键酶:羟甲基戊二酰辅酶A还原酶和保幼激素酸甲基转移酶作了详细介绍。还从家蚕基因组数据库(http://silkworm.genomics.org.cn)中推测出了JH合成途径中大部分酶的编码基因,初探了JH合成的调节机制,讨论了JH合成的研究趋势。

关键词: 保幼激素, 合成酶, 神经肽, 家蚕

Abstract: Juvenile hormones (JHs) are a group of sesquterpenoids synthesized via the mevalonic acid pathway. This review summarized all enzymes involved in the JH synthesis pathway at the molecular level with the ubiquitous JH Ⅲ in insects as example. Furthermore, it introduced two key enzymes: 3-hydroxy-3-methylglutaryl CoA reductase and juvenile hormone acid methyltransferase in detail. In addition, from the silkworm database (http://silkworm.genomics.org.cn), most genes encoding enzymes in the JH synthesis pathway were predicted. Finally, the regulatory mechanism of JH synthesis was discussed and its research direction predicted.

Key words: Juvenile hormone, synthesis enzyme, neuropeptide, Bombyx mori