关键词: 转基因作物, 抗性管理, 高剂量/庇护所策略, 抗性基因频率, 随机交配

Abstract: The high dose/refuge strategy is being applied primarily in field for the resistance management of Bt crops, and its success depends on three essential assumptions. These three assumptions are：(1) Bt-engineered crops must produce a high dose of Bt insecticidal protein to kill most heterozygotes; (2) Initial frequency of alleles conferring resistance in target pest species must be rare; (3) Susceptible adults that survived in refuges are expected to intermingling and mating with resistant adults that survived in Bt fields. We reviewed theoretical and empirical results related to these assumptions, and focused on the recent advances in random mating assumption and presented some new theoretical outcomes resulted from modeling researches. We also discussed the direction of upcoming researches and related techniques briefly.

Key words: Genetically modified crops, resistance management, high dose/refuge strategy, frequency of alleles conferring resistance, random mating