›› 2015, Vol. 58 ›› Issue (1): 90-98.

• 综述 • 上一篇    下一篇

MicroRNA在昆虫变态及生殖过程中的调控作用

赵连丰#, 宋佳晟#, 周树堂*   

  1. (中国科学院动物研究所, 农业虫害鼠害综合治理研究国家重点实验室, 北京100101)
  • 出版日期:2015-01-20 发布日期:2015-01-20
  • 作者简介:赵连丰, 男, 1990年生, 吉林洮南人, 硕士研究生, 细胞生物学专业, E-mail:zlf237@163.com; 宋佳晟, 男, 1985年生, 博士研究生, 生物化学与分子生物学专业, E-mail:songjiasheng@ioz.ac.cn

MicroRNAs in insect metamorphosis and reproduction

ZHAO Lian-Feng#, SONG Jia-Sheng#, ZHOU Shu-Tang*   

  1. (State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China)
  • Online:2015-01-20 Published:2015-01-20

摘要: MicroRNA(miRNA)是一类广泛存在于真核生物中的小分子非编码RNA,通过抑制靶基因的翻译过程或降解靶基因的mRNA,在转录后水平上调控基因表达。在昆虫中已报道了大量的miRNA,其中部分miRNA的功能得到了解析。在昆虫变态过程中,let-7, miR-100, miR-125, miR-34, miR-14, miR-8, miR-281和 miR-252-3p能够作用于保幼激素或蜕皮激素信号通路,影响昆虫蜕皮、化蛹或翅、足及神经系统的发育。在昆虫生殖阶段,bantam, miR-184和miR-275影响生殖干细胞的分化或卵子发生。本文在介绍miRNA生物合成和作用机制的基础上,重点对昆虫变态与生殖过程中miRNA的最新研究进展进行综述。

关键词: miRNA, 生物合成, 转录后调控, 昆虫变态, 昆虫生殖

Abstract: MicroRNAs (miRNAs), a class of small non-coding RNAs in animals, plants, fungi and viruses, regulate the gene expression at post-transcriptional level through translational repression or mRNA degradation. A large number of miRNAs have been reported in insects, but the number of miRNAs with documented functions is limited. During insect metamorphosis, let-7, miR-100, miR-125, miR-34, miR-14, miR-8, miR-281 and miR-252-3p have been demonstrated to function in juvenile hormone and/or ecdysone mediated signaling pathways and to modulate the development of wings, legs and neuronal system. In insect reproduction, bantam, miR-184 and miR-275 have been found to regulate the differentiation and maintenance of female germ line cells as well as the oogenesis. We summarized here the recent advances in the roles of miRNAs in insect metamorphosis and reproduction.

Key words: miRNA, biosynthesis, post-transcriptional regulation, insect metamorphosis, insect reproduction