Abstract: Developing efficient and environmentally friendly pesticide formulations to minimize chemical residues and pollution to the greatest extent possible is critical to ensure food and ecological security. The development of nanotechnology has provided strategies for the creation of green pesticide formulations in agriculture. Researchers have developed a series of intelligent responsive metal or inorganic nanocarriers that target pathological environments and in vitro physical stimuli from diseases, pests and weeds. These carriers can achieve precise-controllable drug release by responding to endogenous changes in animals and plants such as pH, reactive oxygen species (ROS) and redox conditions, or external stimuli such as temperature and light, and improve the efficiency of disease, pest and weed control. From three aspects of responding to endogenous stimuli, responding to exogenous stimuli and responding to multiple stimuli, in this article we reviewed the current status of research on intelligent responsive nano-based drug delivery systems in the agricultural field, introduced the functional design, functional characteristics, and effects of intelligent responsive nanocarriers to serve as a reference for research on pesticides/nucleic acid drugs and their delivery systems. In the future, intelligent responsive nanodrug delivery systems could be a promising vehicle to enhance drug utilization and realize target-specific drug release.

Key words: Nanodrug delivery system, intelligent response, precise-controllable release, endogenous stimuli, exogenous stimuli, multiple stimuli