溴氰菊酯对神经细胞钙通道和
钙库的激活作用

Abstract

Abstract: he effect of pyrethroid insecticide deltamethrin on mesencephalic originated dopaminergic cell line MN9D was investigated by using the patchclamp and Fura-2 microfluorimetric techniques.Whole cell calcium current recordings showed: deltamethrin activated calcium channels (H-VOCs) and increased the amplitude of calcium currents greatly by about 20.64% in 1 min and 15.48% in 5 min at very low concentration (10^-9 mol/L).Deltamethrin could increase the ［Ca²⁺］I in both normal and calciumfree bath solutions. This indicates deltamethrin could stimulate the calcium store to release the cytosolic free Ca²⁺. We conclude deltamethrin stimulates ［Ca²⁺］I entry through the calcium channels and release of Ca²⁺ from intracellular store. Prolonged elevation of ［Ca²⁺］I will affect many cellular process and cause cytotoxic to the cells.

Key words: deltamethrin, wholecell clamp, HVOCs, ［Ca²⁺］I

GUO Zhen-qun, HE Bing-jun, GAO Yong-chuang, SUN Jin-sheng, LIU An-xi. Active effect of deltamethrin on calcium channels and calcium store of culture neurons[J]., 2000, 43(3): 248-254.

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Active effect of deltamethrin on calcium channels and calcium store of culture neurons

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