Abstract: This paper reviews the effect of recombinant baculovirus insecticides on the predatory and parasitic natural enemies of insect pests, the recombination between recombinant baculovirus and the genome of other organisms and the ecological effect of recombinant baculovirus. So far studies have shown that compared with wild-type baculoviruses，the ecological fitness of recombinant baculoviruses is reduced，thereby reducing the risks to ecosystems and non-target organisms such as predators and parasites. However，the use of the recombinant baculoviruses as biocontrol agents is not risk-free. The long term biosafety of recombinant baculoviruses needs to be profoundly and completely studied.

Key words: biosafety, baculoviruses, wild viruses, recombinant viruses, insecticides, ecological effect