Abstract: This article reported the anti-senile effect of water extraction of Martianus dermestoides adults and larvae by testing the activities of SOD, GSH-Px and CAT and MDA content in blood serum of mice. Water extraction was distilled from adults and larvae of M. dermestoides which were separately reared by the advanced forage (consisting of safflower, medlar, Chinese date and Juglans regia nuts）, rice and wheat bran. We use water extraction of M. dermestoides larvae to clystere the mice which were of a senile model established by injecting D-galactose. The results demonstrated that all the water extraction of M. dermestoides adults reared by three kinds of forage increased the activities of SOD， GSH-Px and CAT (P<0.05 or P<0.01) in blood serum of mice, and decreased the MDA content (P<0.05); the effect of the advanced forage group was stronger than the other two groups, but there were no significant differences among the three groups. SOD and CAT activities in blood serum of the mice which had been clystered with water extraction of M. dermestoides larvae were obviously higher than those of the adults, both reared by the advanced forage (P<0.05); however, there were no significant differences between GSH-Px activity and MDA content. The results suggest that water extraction of both adults and larvae of M. dermestoides have antioxidant activity, amd M. dermestoides can be exploited as a kind of health food with antisenile effect.