House dust mites are one of the most important sources of indoor allergens. The demand for higher quality of indoor environment strengthens as the modern life style becomes more popular, so people pay more and more attention to the allergic diseases caused by environmental factors. This paper reviewed allergenic cross-reactivity between house dust mites and other mites, mollusks (snail),  crustaceans （shrimp）and insects (cockroach, silverfish, non-biting midges,caddisflies,silverfish, non-biting midges, caddisflies, etc.). The review will be helpful for clinical diagnosis of allergy.