Abstract: Studies on the baculovirus envelope proteins are important to reveal the mechanism of viral entry and nuclear transporting and targeting of the envelope proteins and also fundamental for the development of new strategies for insect control. Recent researches showed that the envelope proteins of occlusion-derived virus (ODV) include ODV-E25， ODV-E66， ODV-E56， ODV-E18， ODV-E28， P74， PIF1， PIF2， PIF3， GP41， ODV-EC27， ODV-E35， ODV-EC43，BV/ODV-E26，P91 and ORF 150. This article reviewed the recent research achievements about the structure and function of the baculovirus envelope proteins. Most envelope proteins are related to per os infection, cell cycle regulation, and the trafficking of envelope proteins. The mechanism of trafficking of ODV envelope proteins, their interaction with insect midgut and the OB matrix, and the protein-protein interaction of ODV structural proteins will be the focus of future research.

Key words: Baculovirus, occlusion-derived virus, envelope protein, gene knock-out, nuclear transporting, insect midgut