转基因家蚕的研究进展及应用前景

›› 2011, Vol. 54 ›› Issue (2): 197-210.doi:

• RESEARCH PAPERS • Previous Articles Next Articles

Progress and application prospect of transgenic silkworm

ZHOU Qi-Sheng, YU Qi, LIU Qing-Xin

Online:2011-02-20 Published:2011-03-10

Abstract

Abstract: Transgenic silkworm, Bombyx mori was generated by transferring foreign genes to its chromosome with molecular biological techniques and creating new traits and products, which could keep the generation and reflect the function of foreign genes with high expression. Recent studies showed that the piggyBac was the commonly used vector and the green fluorescent protein gene (GFP) was the commonly used reporter gene in the transgenic silkworm technology, and the success rate of the transgenic silkworm by microinjection was up to 40%. Through using transgenic silkworm technology, the function of BmFtz-F1，BmBLOS2, ETH and CecB genes of silkworm had been illuminated; new silkworm breeds with superior quality, high degree of fine fiber, high tensile strength, high flexibility, different fluorescences, and BmNPV resistance or Micrococcus luteus resistance had been established; and many biologically active proteins, vaccine and special biological materials, such as human type Ⅲ procollagen, human basic fibroblast growth factor, recombinant human serum albumin, human brain-derived neurotrophic factor, human insulin like growth factor I, cat interferon and monoclonal antibody, had been produced. With the further study of transgenic technology, transgenic silkworm products will have a broad application prospect in national defense, military industry, aerospace, medicine and so on.

Key words: Bombyx mori, transgene, vector, reporter gene, bioreactor

ZHOU Qi-Sheng, YU Qi, LIU Qing-Xin. Progress and application prospect of transgenic silkworm[J]., 2011, 54(2): 197-210.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.insect.org.cn/EN/

http://www.insect.org.cn/EN/Y2011/V54/I2/197

[1]	ZHANG Xiang-Le, MA Li, MA Qian, LI Sheng, LIU Su-Ning. Ras signaling pathway promotes the growth of endoreplication cells through activating the expression of transcription factor Myc [J]. , 2018, 61(8): 885-894.
[2]	MENG Zhu, WEN Mao-Yu, KANG Xiao-Li, LU Zhong-Yan, ZHAO Ping, XIA Qing-You. Effects of starvation stress on the glucose and lipid metabolism and the role of BmFoxO in Bombyx mori [J]. , 2018, 61(8): 895-904.
[3]	YIN Ya-Ru, HU Jian, HU Wen-Bo, YANG Cheng-Fei, WANG Kun, LIU Chun, LIN Ying, ZHU Yong, WANG Ling-Yan. Fine mapping of mutant gene in the chinese translucent (oc) mutant of the silkworm, Bombyx mori [J]. , 2018, 61(6): 627-636.
[4]	ZHU Juan, XIE Yu-Chen, CHEN Yan-Rong, TANG Shun-Ming, YI Yong-Zhu, SHEN Xing-Jia. Determination of the promoter activity of diapause-associated sorbitol dehydrogenase genes in the silkworm, Bombyx mori [J]. , 2018, 61(4): 391-397.
[5]	LONG Ding-Pei, HAO Zhan-Zhang, XIANG Zhong-Huai, ZHAO Ai-Chun. Progress in targeted genome editing technology in the silkworm, Bombyx mori [J]. , 2018, 61(3): 371-384.
[6]	SHEN Li, XU Chuan, ZHANG Lei, ZHANG Kui, MAO Jing-Xin, PAN Guang-Zhao, LI Zhong-Yang, HU Ren-Jian, YANG Li-Qun, CUI Hong-Juan. Gene cloning, prokaryotic expression and subcelluar localization of a class C scavenger receptor BmSR-C in the silkworm, Bombyx mori [J]. , 2018, 61(10): 1132-1144.
[7]	YANG Juan-Juan, WANG Yuan-Zhuo, WEI Bo-Fan, XING Qiu-Ting, HAN Yun-Chao, QIAO Hui-Li. Regulation of the expression of chemosensory protein gene csp9 by miR-301 in Bombyx mori [J]. , 2018, 61(10): 1145-1152.
[8]	TANG Fen-Fen, ZHANG Yong-Hong, SHAO Yu-Lan, ZHU Feng, BAI Xing-Rong. Virulence and phylogenetic analysis of Bombyx mori nucleopolyhedrovirus isolates from Yunnan, southwestern China [J]. , 2018, 61(10): 1160-1169.
[9]	FU Wen-Bo, CHEN Bin. Taxonomy and fauna of Culicidae: history and current knowledge [J]. , 2018, 61(1): 122-138.
[10]	ZOU Zhen, KANG Le. Vector biology and vector insects [J]. , 2018, 61(1): 1-10.
[11]	MA Xing-Zhou, LI Fei. Function validation and evolution analysis of miRNA regulation of insect testis stem cell self-renewal associated genes [J]. , 2017, 60(8): 847-856.
[12]	TANG Fen-Fen, ZHENG Ya-Qiang, BAI Xing-Rong, CHEN Bin. Changes in the resistance to nucleopolyhedrovirus and the expression levels of the related antimicrobial peptide and heat shock protein genes in Bombyx mori exposed to short-time heat shock [J]. , 2017, 60(5): 505-512.
[13]	YANG Ji-Gui, PENG Li-Na, LIU Tai-Xing, WU Yun-Fei, DU Guo-Yu, ZHANG Qian, WANG Wei, PAN Min-Hui. Cloning and expression analysis of the Sox family gene BmDichaete in the silkworm, Bombyx mori [J]. , 2017, 60(5): 513-522.
[14]	LIAO Wen-Li, Bu Xiao-Ling, Jiang Wan-Yi, Liu Ji-Sheng. Influence of lipopolysaccharide on the expression of the Toll-like receptor gene BmToll9-2 in larval Bombyx mori [J]. , 2017, 60(4): 372-378.
[15]	BAO Xi-Yan, Chen-Peng, LIU Tai-Xing, Wang-La, Liu Wen-Bo, Pan Min-Hui, Lu-Cheng. Advances in apoptosis-related genes in the silkworm， Bombyx mori [J]. , 2017, 60(4): 487-498.

Progress and application prospect of transgenic silkworm

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 0