›› 2015, Vol. 58 ›› Issue (4): 437-444.

• 综述 • 上一篇    下一篇


刘雅婷1,2, 谢文2, 张友军2,*   

  1. (1. 湖南农业大学植物保护学院, 长沙 410128; 2. 中国农业科学院蔬菜花卉研究所, 北京 100081)
  • 出版日期:2015-04-20 发布日期:2015-04-20
  • 作者简介:刘雅婷, 女, 1990年2月生, 湖南省郴州人, 硕士研究生, 研究方向为昆虫生理与分子生物学, E-mail: liuyating19900209@163.com

Research progress in sex determination in insects

LIU Ya-Ting1,2, XIE Wen2, ZHANG You-Jun2,*   

  1. (1. College of Plant Protection, Hunan Agricultural University, Changsha 410128, China; 2. Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China)
  • Online:2015-04-20 Published:2015-04-20

摘要: 阐述昆虫的性别决定机制是理解昆虫性别分化调控的理论基础,也为人类有效控制害虫开辟了新方向。昆虫性别决定机制存在复杂性和多样性,但主要是内因即性别决定基因级联互作调控的结果。本文对近年来基于性别决定基因级联互作的昆虫性别决定机制研究进行了综述,主要包括性别决定基因概况和重要性别决定相关基因的分子级联互作关系。目前发现昆虫重要性别决定相关基因主要集中在常染色体上,且部分基因之间存在紧密的级联互作,如S xl , tra, dsx, csdfem 等。在这些基因中,tra/femdsx 的调控模式在已报道的昆虫中存在共性,即 tra dsx 相对较保守且 tra 通过性特异剪切来调控下游 dsx 的转录形式。目前大多数昆虫的性别决定机制还不清楚,但近年来模式昆虫性别决定机制取得了一定进展,对非模式昆虫的研究还处于起步阶段但却越来越受到重视。

关键词: 昆虫, 性别决定机制, 级联调控; , transformer 基因; , doublesex 基因, 可变剪切

Abstract: Clarifying insect sex determination mechanisms can lay a strong theoretical basis for sex-ratio manipulation, and can also help us to develop new ways for effective pest control. Insects have evolved a bewildering diversity of mechanisms to generate the two sexes. However, the sexual development of an insect is mainly defined through a hierarchical control of several sex determining genes. This article summarized the recent studies and progress in sex determination mechanisms in model insects, focusing on genes and their cascade interactions involved in sex determination. Previous studies have demonstrated that the important sex determination genes are mainly located on autosome, and some of them have close cascade interactions, such as Sxl, tra,dsx, csd, fem, etc. Among these genes, tra and  dsx are functionally conserved, and tra regulates the transcription of the downstream gene—dsx through sex-specific alternative splicing. The tra/femdsx mode of sex determination is prevalent in most studied insects. Although sex determination mechanisms in most insects remain largely unclear, the study of sex determination mechanisms in some model insects has achieved great progress in recent years. Moreover, the mechanism study of sex determination in nonmodel insects has attracted extensive attention though it is still in its infancy stage.

Key words: Insects, sex determination mechanism, hierarchical regulation; , transformer gene, doublesex gene, alternative splicing