Abstract: To evaluate the effects of lowering hyperlipemia of the chewing tablets of oligochitosan from housefly larvae and assess its security, 50 rats were divided into 5 experimental groups. One control group was fed with common feed, another control group was  fed with high fattiness feed, and three treatment groups were fed with different dosage of tablets of oligochitosan from housefly larvae and high fattiness feed, respectively. After 28 days, the content of total cholesterol （TC）, triglyceride (TG) and high density lipoprotein cholesterol (HDLC)in the serum of rats were measured. The acute toxicity of the chewing tablets of oligochitosan was studied according to the guidelines of Chinese Traditional Medicine Pre-clinical Trial. The toxicosis reaction and death number of the mouse were recorded successively for 7 days, and then its LD₅₀ were calculated accordingly. The results showed that when rats were treated with the chewing tablets of oligochitosan, the contents of TC, TG in rat serum decreased remarkably but HDLC increased significantly. The results suggest that the chewing tablets of oligochitosan from housefly larvae may assist in lowering  hyperlipemia. The result of acute toxicity study showed its LD₅₀ exceeded 10 g/kg·bw, which indicated that the chewing tablets was a safe product.
 

Key words: Housefly larvae, oligochitosan, lowering hyperlipemia, LD₅₀