Abstract: Effect of larval oil of Chrysomyia megacephala (Fabricius) on hyperlipemia was studied. Hyperlipemia model was established in mice. The oil in different dose was garaged to the mice for 5 weeks. Blood samples were sampled. The levels of blood lipids were detected. The pathological changes in the liver were observed microscopically. The results showed that larval oil of C. megacephala could obviously reduce contents of triglyceride (TC), TG, and low-density lipoprotein cholesterol (LDL-C) (P<0.05 or P<0.01). Compared to the concentration of total cholesterin (TG) in HFD group model, the concentration of TG in low dose group, medium dose group and high dose group decreased by 20.70%, 48.98% and 56.06%, respectively. The concentration of TC in serum in HFD group model was 4.59 mmol/L. The concentration of TC in larva oil of C. megacephala in low dose group, medium dose group, and high dose group decreased by 16.99%, 23.52% and 25.49% compared with that of TC in HFD group model respectively. HDL-C increased significantly (P<0.05): the concentrations of HDL-C in low dose group, medium dose group and high dose group increased by 11.74%, 18.04% and 18.95% compared with that of HDL-C in HFD group model, respectively. The increase of HDL-C (P<0.05) in serum showed a relationship between the quantity and the effect. Successfully feeding the mice with larva oil of C. megacephala had a protection effect to the liver cells. The results suggest that larval oil of C. megacephala may have a therapeutic effect on hyperlipemia.

Key words: Chrysomyia megacephala, larval oil, hyperlipemia, mice